Spike/Wave Detection

Spike Detection Has Never Been Easier

Spike/wave discharges are epileptogenic brain abnormalities and serve as crucial biomarkers in epilepsy diagnosis. Traditional scalp EEG analysis relies on expert manual interpretation, which is time-consuming due to the large volume of data and high professional requirements. The high threshold for brain data analysis and long learning curve, combined with a shortage of high-level epilepsy specialists in primary healthcare settings, has led to many epilepsy patients being unable to receive timely diagnosis and treatment, seriously affecting public health. The EEGX Intelligent EEG Analysis Platform aims to provide high-precision automatic spike/wave annotation, accelerating the EEG interpretation process, enabling early screening of EEG abnormalities, and supporting the national strategy of improving medical resource accessibility.

Spike/Wave Detection
The EEGX Intelligent EEG Analysis Platform provides leading automatic spike annotation functionality, fully automated process with individual spike highlighting.
From "Has Discharge" to "Where is the Discharge"

Traditional spike detection algorithms can only achieve coarse temporal localization and struggle to identify specific electrodes with discharges. As shown in the figure above, traditional algorithms segment raw EEG data into two-second EEG segments to detect spike discharges. However, coarse localization cannot provide detailed information about spike discharges, especially for epilepsy types with dense discharges, such as childhood Rolandic epilepsy, where multiple discharges may occur within one second. The EEGX Intelligent EEG Analysis Platform, through advanced statistical and artificial intelligence analysis, can capture complex spatiotemporal relationships in brain electrical activity, achieving breakthroughs in both temporal and spatial resolution. The spike recognition and localization algorithm can achieve a temporal resolution of 1/500 second, capturing every subtle feature of the discharge. In the spatial dimension, the algorithm can locate specific electrodes where discharges occur, assisting clinical decision-making and providing more evidence for disease diagnosis.

From 'Has Discharge' to 'Where is the Discharge'
From regional identification to precise discharge timing and channel identification
Triangulation: Making Lesions Nowhere to Hide
Triangulation: Making Lesions Nowhere to Hide

Unlike artifact signals, abnormal epileptic discharges deep in the brain typically manifest as scalp electric fields. Thanks to EEGX's high-precision spike localization functionality, the algorithm can quantitatively analyze the morphological features of each spike, calculating its discharge amplitude, average width, and rise/fall slope information. These rich quantitative indicators help doctors quickly identify the main peak and secondary discharge field areas, making lesions nowhere to hide.

Recognition Accuracy Comparable to Human Experts

High recognition accuracy is the relentless pursuit of medical AI. Due to the strong sample imbalance in medical data, balancing algorithm performance between false negatives (1-sensitivity) and false positives (1-specificity) is crucial for clinical applications of medical algorithms. The EEGX Intelligent EEG Analysis Platform, through comparison with numerous normal physiological waveforms and benign variants, has achieved significant improvement in specificity while maintaining high recognition sensitivity, becoming the first spike recognition algorithm comparable to human experts (Reference).

Recognition Accuracy Comparable to Human Experts
*Jing J, Herlopian A, Karakis I, et al. Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms. JAMA Neurol. 2020;77(1):49–57.